Department of Wood Science and Technology (FFWT) - list of publications


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MISHRA, P K. et al. Wood-Based Cellulose Nanofibrils: Haemocompatibility and Impact on the Development and Behaviour of Drosophila melanogaster. Biomolecules. 2019. v. 9, no. 8, ISSN 2218-273X. URL: https://www.mdpi.com/2218-273X/9/8/363

Original name: Wood-Based Cellulose Nanofibrils: Haemocompatibility and Impact on the Development and Behaviour of Drosophila melanogaster
Czech name:
Written by (author): Ing. Pawan Kumar Mishra, Ph.D.
Department: Department of Wood Science and Technology
Kind of publication: article in a professional periodical
Periodical: Biomolecules
Nature of article: paper
Volume no. (year): 9
Periodical number within the volume: 8
Year of publication: 2019
Starting page:
Up to page:
Number of pages: 13
Sub-specification: článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication: printed version
Original language: English
Description in original language: Wood-based cellulose nanofibrils (CNF) offer an excellent scaffold for drug-delivery formulation development. However, toxicity and haemocompatibility of the drug carrier is always an important issue. In this study, toxicity-related issues of CNF were addressed. Different doses of CNF were orally administered to Drosophila and different tests like the developmental cycle, trypan blue exclusion assay, larva crawling assay, thermal sensitivity assay, cold sensitivity assay, larval light preference test, climbing behaviour, nitroblue tetrazolium (NBT) reduction assay, adult phenotype, and adult weight were conducted to observe the impact on its development and behaviour. A haemocompatibility assay was done on the blood taken from healthy Wistar rats. In Drosophila, the abnormalities in larval development and behaviour were observed in the behavioural assays. However, the cytotoxic effect could not be confirmed by the gut staining and level of reactive oxygen species. The larvae developed into an adult without any abnormality in the phenotype. The CNF did cause loss of weight in the adult flies and did not cause much toxicity within the body since there was no phenotypic defect. Hemolysis data also suggested that CNF was safe at lower doses, as the data was well within acceptable limits. All these results suggest that cellulose nanofibres have no significant cytotoxic effects on Drosophila. However, the developmental and behavioural abnormalities suggest that CNF may act as a behavioural teratogen.
Description in English:
Description in Czech:
Year of submission: 2019
Year of transmission:
RIV identification number:
URL: https://www.mdpi.com/2218-273X/9/8/363
 
Entry made by: Markéta Hejčová, DiS.
Last change: 08/30/2019 09:30 (Šárka Novotná)

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Source specification:

Biomolecules. Basel: ISSN 2218-273X.

Original name: Biomolecules
Czech name:
Written by (author):
Kind of publication: magazine
ISSN: 2218-273X
Country of publisher: Swiss Confederation
Place of publishing: Basel
Publisher: Multidisciplinary Digital Publishing Institute-MDPI
URL:
Reviewed magazine: no
Original language: English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by: Markéta Hejčová, DiS.
Last change: 08/30/2019 09:30 (Šárka Novotná)

Evaluation of publication:

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12345
bad
 
good        uninteresting
 
interesting
Assessed: 0Average score: -        Assessed: 0Average score: -
12345
        
12345
amateur
 
professional        theoretical
 
practical
Assessed: 0Average score: -        Assessed: 0Average score: -