Mendel University in Brno - list of publicationsHelp


The following list contains all information available to the publication.

HIRSOVA, P. -- BOHM, F. -- DOHNÁLKOVÁ, E. -- NOZICKOVA, B. -- HEIKENWALDER, M. -- GORES, G J. -- WEBER, A. Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis. Cell Death & Disease. 2020. v. 11, no. 2, ISSN 2041-4889. URL: https://www.nature.com/articles/s41419-020-2283-9

Original name:
Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis
Czech name:
Written by (author):
Petra Hirsova
Friederike Bohm
Mgr. Ester Dohnálková
Barbora Nozickova
Mathias Heikenwalder
Gregory J Gores
Achim Weber
Department:
Department of Chemistry and Biochemistry
Kind of publication: article in a professional periodical
Periodical:
Cell Death & Disease
Nature of article: paper
Volume no. (year):
11
Periodical number within the volume:
2
Year of publication:
2020
Starting page:
Up to page:
Number of pages:
12
Sub-specification:
článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language:
English
Description in original language:
Nonalcoholic fatty liver disease is the most common chronic liver disease and may progress to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The molecular determinants of this pathogenic progression, however, remain largely undefined. Since liver tumorigenesis is driven by apoptosis, we examined the effect of overt hepatocyte apoptosis in a mouse model of NASH using mice lacking myeloid cell leukemia 1 (Mcl1), a pro-survival member of the BCL-2 protein family. Hepatocyte-specific Mcl1 knockout (Mcl1(hep)) mice and control littermates were fed chow or FFC (high saturated fat, fructose, and cholesterol) diet, which induces NASH, for 4 and 10 months. Thereafter, liver injury, inflammation, fibrosis, and tumor development were evaluated biochemically and histologically. Mcl1(hep) mice fed with the FFC diet for 4 months displayed a marked increase in liver injury, hepatocyte apoptosis, hepatocyte proliferation, macrophage-associated liver inflammation, and pericellular fibrosis in contrast to chow-fed Mcl1(hep) and FFC diet-fed Mcl1-expressing littermates. After 10 months of feeding, 78% of FFC diet-fed Mcl1(hep) mice developed liver tumors compared to 38% of chow-fed mice of the same genotype. Tumors in FFC diet-fed Mcl1(hep) mice were characterized by cytologic atypia, altered liver architecture, immunopositivity for glutamine synthetase, and histologically qualified as HCC. In conclusion, this study provides evidence that excessive hepatocyte apoptosis exacerbates the NASH phenotype with enhancement of tumorigenesis in mice.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
URL:
https://www.nature.com/articles/s41419-020-2283-9
 
Entry made by:
Last change:
02/24/2020 07:45 (Šárka Novotná)

Evaluation of publication:

1
2
34
5
        
12345
bad
 
good
        
uninteresting
 
interesting
Assessed: 0
Average score: -
        
Assessed: 0
Average score: -
123
4
5
        
1
2
3
4
5
amateur
 
professional
        
theoretical
 
practical
Assessed: 0
Average score: -        
Assessed: 0
Average score: -


Source specification:

Cell Death & Disease. London: ISSN 2041-4889.

Original name: Cell Death & Disease
Czech name:
Written by (author):
Kind of publication:
magazine
ISSN:
2041-4889
Country of publisher:
United Kingdom of Great Britain and Northern Ireland
Place of publishing: London
Publisher:
Nature Publishing Group
URL:
https://www.nature.com/cddis/
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by: Markéta Hejčová, DiS.
Last change:
02/24/2020 07:45 (Šárka Novotná)

Evaluation of publication:

1
2
3
4
5
        
1
2
3
4
5
bad
 
good
        
uninteresting
 
interesting
Assessed: 0
Average score: -
        Assessed: 0Average score: -
1
23
4
5
        
1
2
3
4
5
amateur
 
professional
        
theoretical
 
practical
Assessed: 0Average score: -
        
Assessed: 0Average score: -