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GAGIĆ, M. -- KOČIOVÁ, S. -- ŠMERKOVÁ, K. -- MICHÁLKOVÁ, H. -- SETKA, M. -- ŠVEC, P. -- PŘIBYL, J. -- MASILKO, J. -- BÁLKOVÁ, R. -- HEGER, Z. -- RICHTERA, L. -- ADAM, V. -- MILOSAVLJEVIĆ, V. One-pot synthesis of natural amine-modified biocompatible carbon quantum dots with antibacterial activity. Journal of Colloid and Interface Science. 2020. v. 580, no. November, p. 30--48. ISSN 0021-9797.

Original name:
One-pot synthesis of natural amine-modified biocompatible carbon quantum dots with antibacterial activity
Czech name:
Written by (author): Milica Gagić, Ph.D.
Ing. Silvia Kočiová, Ph.D.
Ing. Kristýna Šmerková, Ph.D.
Ing. Hana Michálková, Ph.D.
Milena Setka
Ing. Pavel Švec, Ph.D.
Jan Přibyl
Jiří Masilko
Radka Bálková
Mgr. Zbyněk Heger, Ph.D.
RNDr. Lukáš Richtera, Ph.D.
prof. RNDr. Vojtěch Adam, Ph.D.
Ing. Vedran Milosavljević, Ph.D.
Department:
Department of Chemistry and Biochemistry
Kind of publication:
article in a professional periodical
Periodical:
Journal of Colloid and Interface Science
Nature of article:
paper
Volume no. (year):
580
Periodical number within the volume:
November
Year of publication:
2020
Starting page:
30
Up to page:
48
Number of pages:
19
Sub-specification:
článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language: English
Description in original language:
In the present study, the thermal decomposition of citric acid in the presence of biogenic amine was used to synthesize four different functionalized carbon quantum dots (CQDs), namely, histamine-(HCQDs), putrescine-(PCQDs), cadaverine-(CCQDs) and spermine-(SCQDs). The thermal decomposition of the precursors resulted in a decrease in stability and the formation of surface amides via a cross-linking process between the carboxyl and amine groups. The deposition of biogenic amines was confirmed by a structural characterization of the synthesized CQDs. The resulting CQDs, with a net zero charge, exhibited excellent stability in environments with different pH values. Through a set of different cytotoxicity tests, the absence of gene mutations, apoptosis, necrosis or disruption in cell membranes revealed the high biocompatibility of the CQDs. The antimicrobial activity of the synthesized CQDs was investigated against different bacterial species (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumonia). We determined the growth kinetics, production of reactive oxygen species (ROS), cell viability and changes in membrane integrity by scanning electron microscopy (SEM). The minimal inhibitory concentrations (MICs) for S. aureus ranged from 3.4 to 6.9 µg/mL. Regarding E. coli and K. pneumonia, all CQD formulations reduced growth, and the MICs were determined for CCQDs and HCQDs (6.9-19.4 µg/mL). The antibacterial activity mechanism was attributed to the oxidative stress generated after CQD treatment, which resulted in the destabilization of the bacterial membrane. The bacterial permeability to propidium iodide indicated a change in membrane integrity, and the effect of CQDs on the morphology of the bacterial cells was evidenced by SEM.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
 
Entry made by:
Last change:
08/03/2020 13:26 (Mgr. Kamila Zoufalá)

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Source specification:

Journal of Colloid and Interface Science. San Diego: ISSN 0021-9797.

Original name:
Journal of Colloid and Interface Science
Czech name:
Written by (author):
Kind of publication: magazine
ISSN:
0021-9797
Country of publisher:
United States of America
Place of publishing:
San Diego
Publisher:
Elsevier Science Inc.
URL:
https://www.sciencedirect.com/journal/journal-of-colloid-and-interface-science
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Last change:
02/05/2019 09:29 (Šárka Novotná)

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