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TESAŘOVÁ, B. -- MUSÍLEK, K. -- REX, S. -- HEGER, Z. Taking advantage of cellular uptake of ferritin nanocages for targeted drug delivery. Journal of Controlled Release. 2020. v. 325, no. September, p. 176--190. ISSN 0168-3659.

Original name:
Taking advantage of cellular uptake of ferritin nanocages for targeted drug delivery
Czech name:
Written by (author):
Ing. Barbora Tesařová, Ph.D.
Kamil Musílek
Ing. Simona Rex, Ph.D.
Mgr. Zbyněk Heger, Ph.D.
Department:
Department of Chemistry and Biochemistry
Kind of publication:
article in a professional periodical
Periodical: Journal of Controlled Release
Nature of article:
paper
Volume no. (year): 325
Periodical number within the volume: September
Year of publication: 2020
Starting page:
176
Up to page:
190
Number of pages:
15
Sub-specification: článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language: English
Description in original language: The search for ideal nanocarrier, which could be rapidly translated to clinical practice, is still ongoing over the past few decades. However, many reviews are focused on important properties of ideal nanocarrier, including long circulation, high internalization efficiency of a drug, surface charge of nanocarrier or the ability to encapsulate high amount of a drug. Indeed, the ability to encapsulate wide variety of drugs, no immunogenicity, biodegradability or nanocarrier monodispersity are very important aspects, therefore they are discussed in this review. The use of nanocarrier formulations able to innately form self-assembly cages of uniform size and shape, employing protein-based structures naturally present in human body, seems to be very promising. Typical protein nanocarrier disposing all the above mentioned characteristics is represented by ferritin (FRT). Hence, the presented review provides detailed characterization of FRT structure, including its disassembly and reassembly properties, which are crucial for encapsulation of drugs, together with possibilities of active targeting, exploiting both the innate affinities of FRT nanocages towards selected receptors and the plethora of surface functional groups that can be used to attach a variety of targeting ligands. Finally, we discuss the opportunities of cutting-edge approaches to FRT-based nanotherapy and the challenges that must be overcome or avoided.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
 
Entry made by:
Mgr. Kamila Zoufalá
Last change:
08/03/2020 12:38 (Mgr. Kamila Zoufalá)

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Source specification:

Journal of Controlled Release. Amsterdam: ISSN 0168-3659.

Original name:
Journal of Controlled Release
Czech name:
Written by (author):
Kind of publication: magazine
ISSN: 0168-3659
Country of publisher:
Kingdom of the Netherlands
Place of publishing:
Amsterdam
Publisher:
Elsevier Science BV
URL:
https://www.journals.elsevier.com/journal-of-controlled-release
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Mgr. Kamila Zoufalá
Last change:
08/09/2019 10:04 (Šárka Novotná)

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