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HRABĚTA, J. -- BELHAJOVA, M. -- ŠUBRTOVÁ, H. -- MERLOS RODRIGO, M Á. -- HEGER, Z. -- ECKSCHLAGER, T. Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition. International Journal of Molecular Sciences. 2020. v. 21, no. 12, ISSN 1661-6596.

Original name: Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition
Czech name:
Written by (author):
Department:
Department of Chemistry and Biochemistry
Kind of publication:
article in a professional periodical
Periodical:
International Journal of Molecular Sciences
Nature of article:
paper
Volume no. (year):
21
Periodical number within the volume:
12
Year of publication:
2020
Starting page:
Up to page:
Number of pages:
18
Sub-specification:
článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language:
English
Description in original language:
Resistance to chemotherapeutics and targeted drugs is one of the main problems in successful cancer therapy. Various mechanisms have been identified to contribute to drug resistance. One of those mechanisms is lysosome-mediated drug resistance. Lysosomes have been shown to trap certain hydrophobic weak base chemotherapeutics, as well as some tyrosine kinase inhibitors, thereby being sequestered away from their intracellular target site. Lysosomal sequestration is in most cases followed by the release of their content from the cell by exocytosis. Lysosomal accumulation of anticancer drugs is caused mainly by ion-trapping, but active transport of certain drugs into lysosomes was also described. Lysosomal low pH, which is necessary for ion-trapping is achieved by the activity of the V-ATPase. This sequestration can be successfully inhibited by lysosomotropic agents and V-ATPase inhibitors in experimental conditions. Clinical trials have been performed only with lysosomotropic drug chloroquine and their results were less successful. The aim of this review is to give an overview of lysosomal sequestration and expression of acidifying enzymes as yet not well known mechanism of cancer cell chemoresistance and about possibilities how to overcome this form of resistance.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
 
Entry made by:
Mgr. Kamila Zoufalá
Last change:
07/20/2020 10:39 (Mgr. Kamila Zoufalá)

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Source specification:

International Journal of Molecular Sciences. ISSN 1661-6596.

Original name:
International Journal of Molecular Sciences
Czech name:
Written by (author):
Kind of publication: magazine
ISSN:
1661-6596
Country of publisher: Swiss Confederation
Place of publishing:
Publisher:
MDPI AG
URL:
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
Year of submission:
Note:
Bylo ukončeno vydávání. Od roku 2013 je ve WoS online verze s ISSN 1422-0067. Jana Kratochvílová (2.4.2014)
Last change: 04/02/2014 11:13 (Bc. Ing. Jana Kratochvílová)

Evaluation of publication:

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