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KOUDELKOVÁ, Z. -- SEDLÁČKOVÁ, E. -- RICHTERA, L. -- ŠVEC, P. -- ADAM, V. Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53. In NANOCON 2019: Conference Proceedings. Ostrava: Tanger Ltd., 2020, p. 402--405. ISBN 978-80-87294-95-6. URL: https://www.confer.cz/nanocon/2019/76-gold-nanoparticles-modified-screen-printed-carbon-electrode-as-a-tool-for-detection-of-tp53

Original name: Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53
Czech name:
Written by (author):
Department:
Department of Chemistry and Biochemistry
Kind of publication:
article in proceedings
Collection:
NANOCON 2019: Conference Proceedings
Nature of article:
paper
Part number:
Starting page:
402
Up to page:
405
Number of pages: 4
UT code by Web of Science:
EID code by Scopus:
Original language:
English
Description in original language:
Cancer is one of the most common causes of death in developing countries and in the developed world. The function of the p53 protein plays an important role in the development of cancer. The protein p53 regulates the expression of genes that are responsible for the control of cell growth, apoptosis or for repair of damaged DNA. It t is encoded by the tumor suppressor gene TP53. If this gene mutates, its product will be damaged. It was found that mutations in the TP53 gene is present in more than 50% of cancer cases. Electrochemical biosensors have proved to be a suitable method for the detection of TP53 and also its mutations. Electrochemical deposition of gold nanoparticles on the surface of working electrode increases the active surface area of the sensor, this leads to a more sensitive detection of the TP53 gene and its mutations. By developing an electrochemical biosensor based on gold nanoparticles modified screen printed electrodes, an efficient platform for detecting the TP53 gene in biological samples is obtained.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
URL: https://www.confer.cz/nanocon/2019/76-gold-nanoparticles-modified-screen-printed-carbon-electrode-as-a-tool-for-detection-of-tp53
 
Entry made by:
Last change:
06/12/2020 10:23 (Markéta Hejčová, DiS.)

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Source specification:

NANOCON 2019: Conference Proceedings. Ostrava: Tanger Ltd., 2020. ISBN 978-80-87294-95-6.

Original name:
NANOCON 2019: Conference Proceedings
English name:
Czech name:
Editor:
Kind of publication:
conference proceedings
ISBN:
978-80-87294-95-6
Publisher:
Tanger Ltd.
Place of publishing:
Ostrava
Form of publication: electronic version (online)
Issue and volume number:
Year of publication: 2020
Issue number:
Number of pages:
Entry:
11th International Conference NANOCON 2019
Original language:
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Last change:
06/12/2020 09:26 (Markéta Hejčová, DiS.)

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Source specification:

11th International Conference NANOCON 2019. 2019, Brno.

Original name: 11th International Conference NANOCON 2019
English name:
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Promoter:
Kind of publication:
holding a conference
Venue: Brno
Organizer:
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Time scope of event:
worldwide event
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Held in year :
2019
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Original language:
Description in original language:
Description in English:
Description in Czech:
Year of transmission:
RIV identification number:
 
Entry made by:
Last change:
06/12/2020 09:26 (Markéta Hejčová, DiS.)

Evaluation of publication:

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