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VAŇOVÁ, V. -- SEDLÁČKOVÁ, E. -- HYNEK, D. -- RICHTERA, L. -- BYTEŠNÍKOVÁ, Z. -- ADAM, V. Highly selective and sensitive electrochemical biosensor based on electrochemically reduced graphene oxide for detection of mirna as a cancer biomarker. In NANOCON 2019: Conference Proceedings. Ostrava: Tanger Ltd., 2020, p. 385--390. ISBN 978-80-87294-95-6. URL: https://www.confer.cz/nanocon/2019/79-highly-selective-and-sensitive-electrochemical-biosensor-based-on-electrochemically-reduced-graphene-oxide-for-detection-of-mirna-as-a-cancer-biomarker

Original name:
Highly selective and sensitive electrochemical biosensor based on electrochemically reduced graphene oxide for detection of mirna as a cancer biomarker
Czech name:
Written by (author):
Department:
Department of Chemistry and Biochemistry
Kind of publication: article in proceedings
Collection:
NANOCON 2019: Conference Proceedings
Nature of article:
paper
Part number:
Starting page:
385
Up to page:
390
Number of pages:
6
UT code by Web of Science:
EID code by Scopus:
Original language:
English
Description in original language:
Nowadays, cancer is one of the most outrageous diseases affecting millions of people throughout the world. In this study, the sensitive biosensor for miRNA-21 detection was developed. Through a facile sulfonamide coupling reaction a miRNA-21 specific DNA hybridization probe was immobilized onto a glassy carbon electrode (GCE) modified with electrochemical reduced graphene oxide (erGO). miRNA is a small non-coding RNA molecule which plays an important role in gene expression. The level of miRNA in extracellular fluids varying in the presence of cancer and it can serve as creates a potential biomarker for early detection of cancer. A higher levelcancer. An elevated level of miRNA-21 represents a common feature of pathological cell growth or cell stress and is connected with almost all types of cancer and with cardiovascular diseases, as well.The aim of this study was improve the electrochemical properties by using erGO as a modification for better sensitivity of the developed biosensor. After the modification with erGO, 1-amino-2-naphthol-4-sulfonic acid (AN-SO3-) was electrodeposited on the GCE surface.Then the GCE was subsequently modified by electrochemical deposition 1-amino-2-naphthol-4-sulfonic acid (AN-SO3-) on the GCE surface. Finally, the amino terminated capture probe was immobilized on the GCE via the sulfonamide coupling reaction. The developed biosensor for the detection of specific miRNA sequence was optimized and modified for using in further experiments.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
URL: https://www.confer.cz/nanocon/2019/79-highly-selective-and-sensitive-electrochemical-biosensor-based-on-electrochemically-reduced-graphene-oxide-for-detection-of-mirna-as-a-cancer-biomarker
 
Entry made by:
Last change:
06/12/2020 09:54 (Markéta Hejčová, DiS.)

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Source specification:

NANOCON 2019: Conference Proceedings. Ostrava: Tanger Ltd., 2020. ISBN 978-80-87294-95-6.

Original name:
NANOCON 2019: Conference Proceedings
English name:
Czech name:
Editor:
Kind of publication:
conference proceedings
ISBN:
978-80-87294-95-6
Publisher:
Tanger Ltd.
Place of publishing:
Ostrava
Form of publication:
electronic version (online)
Issue and volume number:
Year of publication:
2020
Issue number:
Number of pages:
Entry:
11th International Conference NANOCON 2019
Original language:
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Last change:
06/12/2020 09:26 (Markéta Hejčová, DiS.)

Evaluation of publication:

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Source specification:

11th International Conference NANOCON 2019. 2019, Brno.

Original name:
11th International Conference NANOCON 2019
English name:
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Promoter:
Kind of publication: holding a conference
Venue:
Brno
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Time scope of event:
worldwide event
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Held in year :
2019
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Description in original language:
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Description in Czech:
Year of transmission:
RIV identification number:
 
Entry made by: Markéta Hejčová, DiS.
Last change:
06/12/2020 09:26 (Markéta Hejčová, DiS.)

Evaluation of publication:

1
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5
        
1234
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uninteresting
 
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