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ZOUHAR, J. et al. MTV proteins unveil ER- and microtubule-associated compartments in the plant vacuolar trafficking pathway. Proceedings of the National Academy of Sciences of the United States of America. 2020. v. 117, no. 18, p. 9884--9895. ISSN 0027-8424. URL: https://www.pnas.org/content/117/18/9884

Original name:
MTV proteins unveil ER- and microtubule-associated compartments in the plant vacuolar trafficking pathway
Czech name:
Written by (author):
Mgr. Jan Zouhar, Ph.D.
Department:
CEITEC MENDELU
Kind of publication:
article in a professional periodical
Periodical:
Proceedings of the National Academy of Sciences of the United States of America
Nature of article: paper
Volume no. (year):
117
Periodical number within the volume:
18
Year of publication:
2020
Starting page:
9884
Up to page: 9895
Number of pages:
12
Sub-specification:
článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language:
English
Description in original language:
The factors and mechanisms involved in vacuolar transport in plants, and in particular those directing vesicles to their target endomembrane compartment, remain largely unknown. To identify components of the vacuolar trafficking machinery, we searched for Arabidopsis modified transport to the vacuole (mtv) mutants that abnormally secrete the synthetic vacuolar cargo VAC2. We report here on the identification of 17 mtv mutations, corresponding to mutant alleles of MTV2/VSR4, MTV3/PTEN2A MTV7/EREL1, MTV8/ARFC1, MTV9/PUF2, MTV10/VPS3, MTV11/VPS15, MTV12/GRV2, MTV14/GFS10, MTV15/BET11, MTV16/VPS51, MTV17/VPS54, and MTV18/VSR1. Eight of the MTV proteins localize at the interface between the trans-Golgi network (TGN) and the multivesicular bodies (MVBs), supporting that the trafficking step between these compartments is essential for segregating vacuolar proteins from those destined for secretion. Importantly, the GARP tethering complex subunits MTV16/VPS51 and MTV17/VPS54 were found at endoplasmic reticulum (ER)- and microtubule-associated compartments (EMACs). Moreover, MTV16/VPS51 interacts with the motor domain of kinesins, suggesting that, in addition to tethering vesicles, the GARP complex may regulate the motors that transport them. Our findings unveil a previously uncharacterized compartment of the plant vacuolar trafficking pathway and support a role for microtubules and kinesins in GARP-dependent transport of soluble vacuolar cargo in plants.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
URL:
https://www.pnas.org/content/117/18/9884
 
Entry made by:
Last change:
05/29/2020 11:50 (Markéta Hejčová, DiS.)

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Source specification:

Proceedings of the National Academy of Sciences of the United States of America. Washington: ISSN 0027-8424.

Original name: Proceedings of the National Academy of Sciences of the United States of America
Czech name:
Written by (author):
Kind of publication:
magazine
ISSN:
0027-8424
Country of publisher: United States of America
Place of publishing: Washington
Publisher:
National Academy of Sciences
URL:
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Last change:
03/29/2017 08:32 (Šárka Novotná)

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