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MAZUMDAR, A. -- HADDAD, Y A E. -- MILOSAVLJEVIĆ, V. -- MICHÁLKOVÁ, H. -- GURÁŇ, R. -- BHOWMICK, S. -- MOULICK, A. Peptide-Carbon Quantum Dots conjugate, Derived from Human Retinoic Acid Receptor Responder Protein 2, against Antibiotic-Resistant Gram Positive and Gram Negative Pathogenic Bacteria. Nanomaterials. 2020. v. 10, no. 2, ISSN 2079-4991. URL: https://www.mdpi.com/2079-4991/10/2/325

Original name: Peptide-Carbon Quantum Dots conjugate, Derived from Human Retinoic Acid Receptor Responder Protein 2, against Antibiotic-Resistant Gram Positive and Gram Negative Pathogenic Bacteria
Czech name:
Written by (author):
Aninda Mazumdar, Ph.D.
Yazan Abdulmajeed Eyadh Haddad, Ph.D.
Ing. Vedran Milosavljević, Ph.D.
Ing. Hana Michálková, Ph.D.
Mgr. Roman Guráň, Ph.D.
Sukanya Bhowmick, M.Sc.
Amitava Moulick, MSc., Ph.D.
Department:
Department of Chemistry and Biochemistry
Kind of publication: article in a professional periodical
Periodical:
Nanomaterials
Nature of article:
paper
Volume no. (year):
10
Periodical number within the volume: 2
Year of publication: 2020
Starting page:
Up to page:
Number of pages: 19
Sub-specification: článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language:
English
Description in original language:
Antibiotic-resistant bacterial infections have become global issues for public health, which increases the utter need to develop alternatives to antibiotics. Here, the HSER (Homo sapiens retinoic acid receptor) peptide was designed from retinoic acid receptor responder protein 2 of Homo sapiens, and was conjugated with synthesized CQDs (carbon quantum dots) for enhanced antibacterial activity in combination, as individually they are not highly effective. The HSER-CQDs were characterized using spectrophotometer, HPLC coupled with electrospray-ionization quadrupole time-of-flight mass spectrometer (ESI-qTOF) mass spectrometer, zeta potential, zeta size, and FTIR. Thereafter, the antibacterial activity against Vancomycin-Resistant Staphylococcus aureus (VRSA) and Escherichia coli (carbapenem resistant) was studied using growth curve analysis, further supported by microscopic images showing the presence of cell debris and dead bacterial cells. The antibacterial mechanism of HSER-CQDs was observed to be via cell wall disruption and also interaction with gDNA (genomic DNA). Finally, toxicity test against normal human epithelial cells showed no toxicity, confirmed by microscopic analysis. Thus, the HSER-CQDs conjugate, having high stability and low toxicity with prominent antibacterial activity, can be used as a potential antibacterial agent.
Description in English:
Description in Czech:
Year of submission:
2020
Year of transmission:
RIV identification number:
URL:
https://www.mdpi.com/2079-4991/10/2/325
 
Entry made by:
Last change: 02/18/2020 12:36 (Markéta Hejčová, DiS.)

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Source specification:

Nanomaterials. Basel: ISSN 2079-4991.

Original name:
Nanomaterials
Czech name:
Written by (author):
Kind of publication:
magazine
ISSN: 2079-4991
Country of publisher: Swiss Confederation
Place of publishing: Basel
Publisher: MDPI AG (Multidisciplinary Digital Publishing Institute-MDPI)
URL:
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Last change:
10/12/2017 14:59 (Šárka Novotná)

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