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MILOSAVLJEVIĆ, V. -- JAMRÓZ, E. -- GAGIC, M. -- HADDAD, Y A E. -- MICHÁLKOVÁ, H. -- BÁLKOVÁ, R. -- TESAŘOVÁ, B. -- MOULICK, A. -- HEGER, Z. -- RICHTERA, L. -- KOPEL, P. -- ADAM, V. Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery. Biomacromolecules. 2020. v. 21, no. 2, p. 418--434. ISSN 1525-7797. URL: https://pubs.acs.org/doi/10.1021/acs.biomac.9b01175

Original name: Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery
Czech name:
Written by (author): Ing. Vedran Milosavljević, Ph.D.
Ewelina Jamróz
Milica Gagic
Yazan Abdulmajeed Eyadh Haddad, Ph.D.
Ing. Hana Michálková, Ph.D.
Radka Bálková
Ing. Barbora Tesařová
Amitava Moulick, MSc., Ph.D.
Mgr. Zbyněk Heger, Ph.D.
RNDr. Lukáš Richtera, Ph.D.
prof. RNDr. Pavel Kopel, Ph.D.
prof. RNDr. Vojtěch Adam, Ph.D.
Department:
Department of Chemistry and Biochemistry
Kind of publication:
article in a professional periodical
Periodical:
Biomacromolecules
Nature of article: paper
Volume no. (year):
21
Periodical number within the volume:
2
Year of publication: 2020
Starting page: 418
Up to page: 434
Number of pages:
17
Sub-specification: článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language: English
Description in original language:
Minimization of drug side effects is a hallmark of advanced targeted therapy. Herein we describe the synthesis of polysaccharide-based nanocapsules prepared from furcellaran and chitosan via layer-by-layer deposition using electrostatic interaction. Using doxorubicin as a model drug, prepared nanocapsules showed excellent drug loading properties and release influence by pH and stability. Targeted delivery of doxorubicin was achieved by nanocapsule surface modification using homing peptide (seq SMSIARLC). The synthesized nanocapsules possess excellent compatibility to eukaryotic organisms. In the case of nonmalignant cells (PNT1A and HEK-293), toxicity tests revealed the absences of DNA fragmentation, apoptosis, necrosis, and also disruption of erythrocyte membranes. In contrast, results from treatment of malignant cell lines (MDA-MB-231 and PC3) indicate good anticancer effects of synthesized bionanomaterial. Internalization studies revealed the nanocapsule's ability to enter the malignant cell lines by endocytosis and triggering the apoptosis. The occurrence of apoptosis is mostly connected to the presence of ROS and inability of DNA damage reparation. Additionally, the obtained results strongly indicate that peptide modification increases the speed of nanocapsule internalization into malignant cell lines while simultaneously nonmalignant cell lines are untouched by nanocapsules highlighting the strong selectivity of the peptide.
Description in English:
Description in Czech:
Year of submission: 2020
Year of transmission:
RIV identification number:
URL: https://pubs.acs.org/doi/10.1021/acs.biomac.9b01175
 
Entry made by:
Last change:
02/13/2020 08:38 (Markéta Hejčová, DiS.)

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Source specification:

Biomacromolecules. Washington: ISSN 1525-7797.

Original name:
Biomacromolecules
Czech name:
Written by (author):
Kind of publication:
magazine
ISSN:
1525-7797
Country of publisher:
United States of America
Place of publishing:
Washington
Publisher:
American Chemical Society
URL:
Reviewed magazine: no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by:
Last change:
01/14/2020 14:26 (Šárka Novotná)

Evaluation of publication:

1
2
3
4
5
        
1
2
3
4
5
bad
 
good
        
uninteresting
 
interesting
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1
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34
5
        
12
3
4
5
amateur
 
professional        theoretical
 
practical
Assessed: 0Average score: -
        
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Average score: -