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TESAŘOVÁ, B. -- REX, S. -- ŠMÍDOVÁ, V. -- GOLIÁŠOVÁ, Z. -- ŠKUBALOVÁ, Z. -- MICHÁLKOVÁ, H. -- HYNEK, D. -- MICHÁLEK, P. -- POLANSKA, H. -- VACULOVIČOVÁ, M. -- HACEK, J. -- ECKSCHLAGER, T. -- STIBOROVA, M. -- PIRES, A S. -- NEVES, A R M. -- ABRANTES, A M. -- RODRIGUES, T. -- MATAFOME, P. -- BOTELHO, M F. -- TEIXEIRA, P. -- MENDES, F. -- HEGER, Z. Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo therapeutic performance of encapsulated ellipticine. Applied Materials Today. 2020. v. 18, no. March, ISSN 2352-9407. URL: https://doi.org/10.1016/j.apmt.2019.100501

Original name:
Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo therapeutic performance of encapsulated ellipticine
Czech name:
Written by (author):
Ing. Barbora Tesařová, Ph.D.
Ing. Simona Rex, Ph.D.
Ing. Veronika Šmídová
Zita Goliášová
Ing. Zuzana Škubalová, Ph.D.
Ing. Hana Michálková, Ph.D.
Ing. David Hynek, Ph.D.
Ing. Petr Michálek, Ph.D.
Hana Polanska
doc. Mgr. Markéta Vaculovičová, Ph.D.
Jaromir Hacek
Tomas Eckschlager
Marie Stiborova
Ana S Pires
Ana R M Neves
Ana M Abrantes
Tiago Rodrigues
Paulo Matafome
Maria F Botelho
Paulo Teixeira
Fernando Mendes
Mgr. Zbyněk Heger, Ph.D.
Department:
Department of Chemistry and Biochemistry
Kind of publication:
article in a professional periodical
Periodical:
Applied Materials Today
Nature of article:
paper
Volume no. (year):
18
Periodical number within the volume:
March
Year of publication: 2020
Starting page:
Up to page:
Number of pages:
11
Sub-specification: článek je obsažen v databázi Web of Science
UT code by Web of Science:
EID code by Scopus:
Form of publication: printed version
Original language:
English
Description in original language: Surface functionalisations substantially influence the performance of drug delivery vehicles by improving their biocompatibility, selectivity and circulation in bloodstream. Herein, we present the study of in vitro and in vivo behaviour of a highly potent cytostatic alkaloid ellipticine (Elli) encapsulated in internal cavity of ferritin (FRT)-based nanocarrier (hereinafter referred to as FRTElli). In addition, FRTElli surface was functionalised with three different molecular coatings: two types of protective PAS peptides (10- or 20-residues lengths) with sequences comprising amino acids proline (P), alanine (A) and serine (S) (to form PAS-10-FRTElli or PAS-20-FRTElli, respectively), or polyethylene glycol (PEG-FRTElli). All three surface modifications of FRT disposed sufficient encapsulation efficiency of Elli with no premature cumulative release of cargo. Noteworthy, all tested surface modifications displayed beneficial effects on the in vitro biocompatibility. PAS-10-FRTElli exhibited markedly reduced uptake by macrophages compared to PAS-20-FRTElli, PEG-FRTElli or unmodified FRTElli. The exceptional properties of PAS-10-FRTElli were validated by an array of in vitro analyses including formation of protein corona, uptake efficiency or screenings of selectivity of cytotoxicity. In murine preclinical model bearing triple-negative breast cancer (MDA-MB-231) xenograft, compared to free Elli or FRTElli, PAS-10-FRTElli displayed enhanced accumulation of Elli within tumour tissue, while hampering the uptake of Elli into off-target tissues. Noteworthy, PAS-10-FRTElli led to decreased in vivo complement (C3) activation and protein corona formation. Taken together, presented in vivo results indicate that PAS-10-FRTElli represents a promising stealth platform for translation into clinical settings.
Description in English:
Description in Czech:
Key words:
czech: PEGylace, PASylace, ferritin, protinádorová terapie, biokompatibilita, karcinomy prsu
english: Cancer therapy, Biocompatibility, PASylation, Breast carcinoma, PEGylation, Ferritin
Year of submission:
2020
Year of transmission:
RIV identification number:
URL: https://doi.org/10.1016/j.apmt.2019.100501
 
Entry made by:
Last change:
04/05/2020 12:30 (Ing. Veronika Šmídová)

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Source specification:

Applied Materials Today. Amsterdam: ISSN 2352-9407.

Original name: Applied Materials Today
Czech name:
Written by (author):
Kind of publication: magazine
ISSN: 2352-9407
Country of publisher:
Kingdom of the Netherlands
Place of publishing: Amsterdam
Publisher:
Elsevier Science Ltd.
URL:
Reviewed magazine: no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by: Markéta Hejčová, DiS.
Last change: 01/14/2020 14:23 (Šárka Novotná)

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