Department of Economics (FBE) - list of publications


The following list contains all information available to the publication.

LITZMAN, J. -- CHOVANCOVA, Z. -- BEJDÁK, P. -- LITZMAN, M. -- HEL, Z. -- VLKOVA, M. Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase. International Journal of Immunopathology and Pharmacology. 2019. v. 33, no. 10 April, ISSN 0394-6320. URL: https://journals.sagepub.com/doi/full/10.1177/2058738419843381?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Original name: Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase
Czech name:
Written by (author):
Jiri Litzman
Zita Chovancova
Petr Bejdák
Bc. Ing. Marek Litzman, Ph.D.
Zdenek Hel
Marcela Vlkova
Department:
Department of Economics
Kind of publication:
article in a professional periodical
Periodical:
International Journal of Immunopathology and Pharmacology
Nature of article: paper
Volume no. (year):
33
Periodical number within the volume:
10 April
Year of publication:
2019
Starting page:
Up to page:
Number of pages:
10
Sub-specification:
UT code by Web of Science:
EID code by Scopus:
Form of publication:
printed version
Original language:
English
Description in original language:
Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. The plasma levels of granulocyte activation markers elastase and myeloperoxidase were determined using enzyme-linked immunosorbent assay (ELISA) in 46 CVID patients and 44 healthy controls. All CVID patients were in a stable state with no apparent acute infection. In addition, granulocyte activation markers' plasma levels in 24 CVID patients were determined prior to and 1 h following IVIg administration. Neutrophil elastase and myeloperoxidase plasma levels were significantly higher in CVID patients than in healthy controls. Systemic elastase levels were further increased following IVIg administration. In vitro stimulation of 13 CVID patients' whole blood using IVIg in a therapeutically relevant dose for 2 h resulted in a significant increase in plasma elastase levels compared to unstimulated blood. The data presented here indicate that CVID is associated with chronic granulocytic activation which is further exacerbated by administering IVIg. Increased myeloperoxidase and elastase levels may contribute to associated comorbidities in CVID patients.
Description in English:
Description in Czech:
Year of submission: 2019
Year of transmission:
RIV identification number:
URL: https://journals.sagepub.com/doi/full/10.1177/2058738419843381?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
 
Entry made by:
Markéta Hejčová, DiS.
Last change:
05/07/2019 12:23 (Šárka Novotná)

Evaluation of publication:

1
23
4
5
        
12
3
4
5
bad
 
good
        
uninteresting
 
interesting
Assessed: 0
Average score: -
        
Assessed: 0
Average score: -
1
2
345
        
1
2
3
4
5
amateur
 
professional
        
theoretical
 
practical
Assessed: 0
Average score: -
        
Assessed: 0Average score: -


Source specification:

International Journal of Immunopathology and Pharmacology. Thousand Oaks: ISSN 0394-6320.

Original name:
International Journal of Immunopathology and Pharmacology
Czech name:
Written by (author):
Kind of publication:
magazine
ISSN:
0394-6320
Country of publisher:
United States of America
Place of publishing:
Thousand Oaks
Publisher: Sage Publications
URL: https://journals.sagepub.com/home/iji
Reviewed magazine:
no
Original language:
English
Description in original language:
Description in English:
Description in Czech:
 
Entry made by: Markéta Hejčová, DiS.
Last change:
05/07/2019 12:24 (Šárka Novotná)

Evaluation of publication:

123
4
5
        
1
2
3
4
5
bad
 
good
        
uninteresting
 
interesting
Assessed: 0
Average score: -
        
Assessed: 0
Average score: -
12
3
4
5
        
1
2
3
4
5
amateur
 
professional
        
theoretical
 
practical
Assessed: 0
Average score: -
        
Assessed: 0
Average score: -